Skin changes: A taxonomic approach to the interaction between visitors and residents in receiving communities

Las migraciones en el mundo, dentro de las cuales se pueden considerar los viajes y el turismo, presentan condiciones nuevas así como distintos patrones de movilidad. Los desplazamientos generan particularidades en las relaciones y comportamientos que se verifican entre los participantes, que pueden y deben ser diferenciados en los análisis para una mejor comprensión de esas interacciones y los factores que entran en juego. Los visitantes tienen, además, una dinámica que está conformada por factores diferenciables donde la cultura nacional y la de fuera se encuentran, dando lugar a manifestaciones específicas de esas interacciones. En este texto se busca una aproximación teórica conceptual a la dinámica que se manifiesta en esas interacciones y busca una taxonomía derivada de la complejidad establecida en las interacciones y que se encuentran más allá de la categorización de turistas y anfitriones. Los aportes surgidos de las teorías de la interacción social permiten recuperar ciertos niveles de complejidad presentes en los tipos de interacción donde se ponen en juego posibilidades interpretativas desde los diferentes marcos culturales de los participantes así como desde sus posiciones en las relaciones sociales estructuradas. Este es un elemento que se constituye en el eje de las interacciones y de las interpretaciones entre residentes y viajeros (migrantes), ya sean estos transitorios ---turistas--- o turisgrantes---, personas que combinan ambas condiciones porque su calidad migratoria resulta ser simultáneamente transitoria y su conducta es cercana a la del migrante

Learning strategies and academic performance in students of a private denominational university

Learning strategies and academic performance is a topic to be reconsidered in Higher Education during the pandemic. The objective of the research is to determine the correlation between ACRA learning strategies and academic performance in students of the first three cycles of the Administration School of a private confessional university. The materials consisted of the questionnaire called the Adaptation, Coding, Recovery and Support (ACRA) scale and the notes of the study subjects. The general method was the hypothetical-deductive one and the statistical one as the specific method. The main results consisted of how the students of Communication II and National Reality achieved 100% at the low level such as social interactions and extrinsic and intrinsic motivation. In addition, all three groups scored low on acquisition strategies in their evaluations. The main conclusion was that both variables have a significant relationship, because according to Spearman's Rho 0.821, a high positive correlation is indicated in the university higher educational organization

Plan estratégico de la marca Biciklo para el ingreso al mercado limeño de bicicletas

Biciklo es una marca reconocida internacionalmente que ingresará al mercado limeño ofreciendo bicicletas de alta calidad e innovadoras a precios competitivos. La marca ingresará en tres segmentos: montaña con el modelo Montano, carrera con el modelo Speedo y recreación con el modelo Eskapi. Debido a la pandemia del Covid-19, el uso de bicicleta en Lima se ha intensificado. Biciklo busca ingresar al mercado de bicicletas de gama media-alta, el cual está cubierto en más del 50 % por una sola empresa. Mediante un sólido plan de marketing, la empresa busca posicionarse y alcanzar el 25 % del market share al quinto año. La inversión inicial para el funcionamiento de la empresa y la comercialización será de S/ 800,000. Se espera que las estrategias de marketing permitan contar con un crecimiento de ventas anual superior a 40 % en los primeros cinco años. El estudio de mercado demostró que existe una demanda en crecimiento para bicicletas de este tipo. Por ello, Biciklo se enfocará en un grupo de la población que está dispuesto a pagar más de S/ 2,000 por una bicicleta de calidad. Para el desarrollo del proyecto, Biciklo considera el personal mínimo indispensable, ya que se encuentra en una etapa inicial de operaciones; sin embargo, para la empresa es importante mantener un buen clima laboral y ofrecer línea de carrera a sus colaboradores a lo largo de los años. Para este proyecto, Biciklo está considerando como inversión inicial el monto de S/ 800,000, que casi en su totalidad será financiado por la casa matriz de Biciklo; se estima obtener un margen neto de utilidad promedio de 12 % en los primeros cinco años. Finalmente, los autores de esta investigación concluyen que Biciklo tiene una gran oportunidad de posicionarse en el mercado limeño

Cancer immunotherapy in special challenging populations: recommendations of the Advisory Committee of Spanish Melanoma Group (GEM)

Cancer immunotherapy based on the use of antibodies targeting the so-called checkpoint inhibitors, such as programmed cell death-1 receptor, its ligand, or CTLA-4, has shown durable clinical benefit and survival improvement in melanoma and other tumors. However, there are some special situations that could be a challenge for clinical management. Persons with chronic infections, such as HIV-1 or viral hepatitis, latent tuberculosis, or a history of solid organ transplantation, could be candidates for cancer immunotherapy, but their management requires a multidisciplinary approach. The Spanish Melanoma Group (GEM) panel in collaboration with experts in virology and immunology from different centers in Spain reviewed the literature and developed evidence-based guidelines for cancer immunotherapy management in patients with chronic infections and immunosuppression. These are the first clinical guidelines for cancer immunotherapy treatment in special challenging populations. Cancer immunotherapy in chronically infected or immunosuppressed patients is feasible but needs a multidisciplinary approach in order to decrease the risk of complications related to the coexistent comorbidities

Overview of recent TJ-II stellarator results

The main results obtained in the TJ-II stellarator in the last two years are reported. The most important topics investigated have been modelling and validation of impurity transport, validation of gyrokinetic simulations, turbulence characterisation, effect of magnetic configuration on transport, fuelling with pellet injection, fast particles and liquid metal plasma facing components. As regards impurity transport research, a number of working lines exploring several recently discovered effects have been developed: the effect of tangential drifts on stellarator neoclassical transport, the impurity flux driven by electric fields tangent to magnetic surfaces and attempts of experimental validation with Doppler reflectometry of the variation of the radial electric field on the flux surface. Concerning gyrokinetic simulations, two validation activities have been performed, the comparison with measurements of zonal flow relaxation in pellet-induced fast transients and the comparison with experimental poloidal variation of fluctuations amplitude. The impact of radial electric fields on turbulence spreading in the edge and scrape-off layer has been also experimentally characterized using a 2D Langmuir probe array. Another remarkable piece of work has been the investigation of the radial propagation of small temperature perturbations using transfer entropy. Research on the physics and modelling of plasma core fuelling with pellet and tracer-encapsulated solid-pellet injection has produced also relevant results. Neutral beam injection driven Alfvénic activity and its possible control by electron cyclotron current drive has been examined as well in TJ-II. Finally, recent results on alternative plasma facing components based on liquid metals are also presentedThis work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014–2018 under Grant Agreement No. 633053. It has been partially funded by the Ministerio de Ciencia, Inovación y Universidades of Spain under projects ENE2013-48109-P, ENE2015-70142-P and FIS2017-88892-P. It has also received funds from the Spanish Government via mobility grant PRX17/00425. The authors thankfully acknowledge the computer resources at MareNostrum and the technical support provided by the Barcelona S.C. It has been supported as well by The Science and Technology Center in Ukraine (STCU), Project P-507F

Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study

Background: In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak. Methods: From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study. Results: A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM. Conclusion: Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide

Common Genetic Variation And Age at Onset Of Anorexia Nervosa

Background Genetics and biology may influence the age at onset of anorexia nervosa (AN). The aims of this study were to determine whether common genetic variation contributes to AN age at onset and to investigate the genetic associations between age at onset of AN and age at menarche. Methods A secondary analysis of the Psychiatric Genomics Consortium genome-wide association study (GWAS) of AN was performed which included 9,335 cases and 31,981 screened controls, all from European ancestries. We conducted GWASs of age at onset, early-onset AN (< 13 years), and typical-onset AN, and genetic correlation, genetic risk score, and Mendelian randomization analyses. Results Two loci were genome-wide significant in the typical-onset AN GWAS. Heritability estimates (SNP-h2) were 0.01-0.04 for age at onset, 0.16-0.25 for early-onset AN, and 0.17-0.25 for typical-onset AN. Early- and typical-onset AN showed distinct genetic correlation patterns with putative risk factors for AN. Specifically, early-onset AN was significantly genetically correlated with younger age at menarche, and typical-onset AN was significantly negatively genetically correlated with anthropometric traits. Genetic risk scores for age at onset and early-onset AN estimated from independent GWASs significantly predicted age at onset. Mendelian randomization analysis suggested a causal link between younger age at menarche and early-onset AN. Conclusions Our results provide evidence consistent with a common variant genetic basis for age at onset and implicate biological pathways regulating menarche and reproduction.Peer reviewe

Rhinitis associated with asthma is distinct from rhinitis alone: TARIA‐MeDALL hypothesis

Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one-airway-one-disease,” coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the “Epithelial Barrier Hypothesis.” This review determined that the “one-airway-one-disease” concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme “allergic” (asthma) phenotype combining asthma, rhinitis, and conjunctivitis.info:eu-repo/semantics/publishedVersio

ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice

Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.Peer reviewe